Table 3.
Baseline characteristics, ovarian stimulation data and IVF/ICSI outcomes in the low, medium and high FORT groups.
| Low FORT (n=516) | Medium FORT (n=529) | High FORT (n=496) | P-value | |
|---|---|---|---|---|
| Age | 29.33±3.57 | 29.38±3.45 | 29.39±3.67 | 0.799 |
| Duration of infertility (year) | 3.99±2.53 | 3.84±2.44 | 3.99±2.62 | 0.969 |
| Body mass index (kg/m2) | 23.06±3.50 | 23.34±3.74 | 22.36±3.34 | 0.080 |
| Day 3 follicle-stimulating hormone (IU/L) | 6.66±1.57 | 6.59±1.56 | 6.64±1.61 | 0.837 |
| Day 3 oestradiol (pg/ml) | 31.08±8.19 | 31.10±8.14 | 30.96±8.09 | 0.689 |
| Antral follicle count | 31.63±10.05aa | 26.95±8.30bb | 22.70±6.86cc | 0.000 |
| Pre-ovulatory follicle count | 3.79±1.51aa | 6.12±1.96bb | 9.30±3.06cc | 0.000 |
| Stimulation days | 12.34±3.39 | 12.07±3.09 | 11.78±2.83c | 0.047 |
| Total follicle-stimulating hormone amount (IU) | 1660.98±811.07 | 1654.12±835.76 | 1562.72±684.88c | 0.000 |
| Serum oestradiol on human chorionic gonadotrop day (pg/ml) | 2981.59±1793.93aa | 3421.62±1841.81bb | 4036.08±1984.99cc | 0.000 |
| Retrieved oocyte | 14.31±7.41 | 14.98±7.60b | 16.58±7.37cc | 0.000 |
| MII oocyte | 12.53±6.67a | 13.46±7.09bb | 14.96±6.85cc | 0.000 |
| Fertilized oocyte | 9.01±5.28 | 9.66±5.55b | 10.71±5.55cc | 0.000 |
| Fertilization rate (%) | 72.05±19.17 | 71.97±19.01 | 72.01±18.98 | 0.921 |
| Total number of embryos | 8.31±5.35 | 8.91±5.46b | 9.97±5.56cc | 0.000 |
| Number of high quality embryos | 4.61±3.91 | 4.84±3.69b | 5.47±4.04cc | 0.000 |
| Number of transferred embryos in fresh-embryo cycle | 2.01±0.28 | 2.01±0.22 | 2.00±0.21 | 0.879 |
| Clinical pregnancy rate of fresh-embryo transfer (%) | 65.44 (267/408) | 64.07 (230/359) | 64.29 (189/294) | 0.379 |
| Pregnancy loss rate of fresh-embryo transfer (%) | 19.10 (51/267) | 16.52 (38/230) | 21.16 (40/189) | 0.229 |
| Live birth rate of fresh-embryos transfer (%) | 51.96 (212/408) | 52.65 (189/359) | 49.32 (145/294) | 0.179 |
| Freeze-all rate (%) | 20.93 (108/516)aa | 32.14 (170/529)bb | 40.73 (202/496)cc | 0.000 |
| Number of frozen embryo transfer cycle | 276 | 311 | 370 | – |
| Clinical pregnancy rate of frozen-embryo transfer (%) | 56.88 (157/276) | 52.09 (162/311) | 58.11 (215/370) | 0.149 |
| Pregnancy loss rate of frozen-embryos transfer (%) | 19.11 (30/157) | 19.14 (31/162) | 11.37 (24/211) | 0.459 |
| Live birth rate of frozen-embryo transfer (%) | 43.48 (120/276) | 40.84 (127/311)b | 51.35 (190/370)c | 0.016 |
| Cumulative live birth rate (%) | 64.34 (332/516) | 59.74 (316/529)b | 67.68 (335/496) | 0.032 |
a
and aa denotes P<0.05 or <0.001 between low and middle FORT groups;
b
and bb denotes P<0.05 or <0.001 between middle and high FORT groups;
c
and cc denotes P<0.05 or <0.001 between low and high FORT groups.