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. Author manuscript; available in PMC: 2021 Nov 9.
Published in final edited form as: Cancer Cell. 2020 Oct 22;38(5):672–684.e6. doi: 10.1016/j.ccell.2020.09.014

Figure 1. DrugCell Design.

Figure 1.

(A) DrugCell uses a modular neural network design that combines conventional artificial neural networks (ANN) with a visible neural network (VNN) to make drug response predictions.

(B) Binary encodings of individual genotypes are processed through a VNN with architecture guided by a hierarchy of cell subsystems, with multiple neurons assigned per subsystem.

(C) Compound chemical structures are processed through an ANN using the Morgan fingerprint as input features.