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. Author manuscript; available in PMC: 2021 Aug 4.
Published in final edited form as: J Am Chem Soc. 2020 Oct 22;142(44):18753–18757. doi: 10.1021/jacs.0c08992

Figure 5.

Figure 5.

Proposed model for C-F bond session and cofactor biogenesis in F2-Tyr272 GAOV. A copper-bound superoxide radical oxidizes Cys228 and produces a copper-bound hydroperoxide and a thiol radical. Oxidation of F2-Tyr272 by the thiol radical leads to the formation of a thioether bond and Cu(II)-(F-Tyr•-Cys).