Table 3.

Serum Protein Analyses, PrePF versus No Fibrosis

Protein	Coefficient	P Value	FDR	Same Direction as Plasma?
ALB	−0.07	0.04	0.07	Yes
APOA4*	0.06	0.34	0.40	No
GSN	−0.09	0.04	0.08	Yes
C9	0.18	0.06	0.09	Yes
LBP	0.20	0.03	0.07	Yes
C1QC	−0.14	0.002	0.02	Yes
CRISP3	−0.32	0.04	0.07	Yes
BASP1	−0.04	0.56	0.58	Yes
CRKL	−0.13	0.08	0.12	Yes
SPARC	0.27	0.01	0.05	Yes

Definition of abbreviations: FDR = false discovery rate; PrePF = preclinical pulmonary fibrosis.

Of the 12 significant proteins identified in plasma analysis, 10 were able to be detected in serum samples to allow for comparison between groups. Analysis was controlled for family relatedness.

^*Indicates different directionality than in the plasma samples.