Table 3.
Biological data of 4-alkoxyphenylglycinamides containing aromatics
 | ||||
|---|---|---|---|---|
| Compound | Structure | R | cAMP pEC50 (EC50, nM)a | Emaxb |
| 55 | A |  |
6.61 ± 0.02 (245) | 90 ± 9 |
| 56 | A |  |
6.66 ± 0.08 (219) | 93 ± 4 |
| 57 | A |  |
6.21 ± 0.02 (617) | 95 ± 5 |
| 58 | A |  |
6.23 ± 0.08 (589) | 103 ± 4 |
| 59 | A |  |
6.06 ± 0.05 (871) | 104 ± 2 |
| 60 | A |  |
6.57 ± 0.09 (269) | 98 ± 4 |
| 61 | B |  |
6.26 ± 0.06 (550) | 90 ± 2 |
| 62 | B |  |
6.14 ± 0.03 (724) | 103 ± 0 |
| 63 | B |  |
6.34 ± 0.03 (457) | 104 ± 3 |
| 64 | B |  |
6.17 ± 0.05 (676) | 94 ± 5 |
| 65 | B |  |
6.13 ± 0.04 (741) | 103 ± 3 |
| 66 | B |  |
6.00 ± 0.05 (1000) | 116 ± 9 |
| 67 | B |  |
5.44 ± 0.04 (3631) | 111 ± 0 |
| 68 | B |  |
5.31 ± 0.04 (4898) | 114 ± 6 |
| 69 | B |  |
5.29 ± 0.08 (5129) | 108 ± 4 |
a
pEC50 values are means ± standard error of at least three independent experiments performed in duplicate.
b
Emax value is % of RTI-13951-33 (mean ± standard error).