Table 3.

Selection factors (physicochemical characteristics) of excipients for the development of solid dispersion (9110).

Details of excipients for the development of solid dispersion
Commonly used solid carriers	Nature of solid carrier	Commonly used solvent	Melting point (°C)	Boiling point (°C) (vapor pressure at 25 °C)	Remark
Citric acid, tartaric acid, succinic acid, phosphoric acid	Acidic	Water	0	100 (3.16 kPa)	Water soluble solid carriers are suitable for melt method
Sodium acetate, sodium-o-hydroxy benzoate, sodium-p-hydroxy benzoate, sodium citrate, resorcinol, ascorbic acid	Hydrotropes	Methanol	–93.3	65 (16.9 kPa)	Volatile solvent suitable for thermolabile drugs
Dextrose, sorbitol, mannose, sucrose, maltose, galactose, xylitol, lactose, soluble starch, d-glucose, chitosan, galactomannan, amylodextrin, British gum	Sugars	Ethanol	–117	78.5 (5.79 kPa)	Volatile solvent suitable for thermolabile drugs
Gelucire 44/14, Poloxamer F-127, deoxycholic acid, Pluronic F68, Myrj 52, sodium lauryl sulfate, Tween 80, Span 80, vitamin E TPGS, docusate sodium, polyoxyethylene stearate	Surfactants	Ethanol	–117	78.5 (5.79 kPa)	Gelucire and TPGS commonly used
PEG-4000, PEG 6000, polyvinyl pyrrolidone (PVP), β-cyclodextrin, hydroxypropyl-β-cyclodextrin, Eudragit L100 sodium salt, sodium salt of crystalline microcellulose, hydroxy propyl methyl cellulose, methyl cellulose, guar gum, xanthan gum, dextrin	Polymers	Isopropyl alcohol	–127	82.4 (5.85 kPa)	Tackiness observed due to PEG and PVP
Dicalcium phosphate, silica gel, hydroxy alkyl xanthene, urethane, urea, skimmed milk, pentaerythritol	Others	Chloroform	–63	62 (26.1 kPa)	Volatile solvent suitable for thermolabile drugs