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. 2020 Nov 16;7(1):75–85. doi: 10.1002/cjp2.183

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© 2020 The Authors. The Journal of Pathology: Clinical Research published by The Pathological Society of Great Britain and Ireland & John Wiley & Sons, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Morphological and immunohistochemical characteristics of the second case of colorectal combined large cell neuroendocrine carcinoma and squamous cell carcinoma pictured in overview (A) and close‐up view (B–H). Examples of neuroendocrine differentiation are shown by immunostaining for synaptophysin (accentuated in marginal areas; C). Tumour cells exhibit strong expression of β‐catenin (D). The squamous component is again marked with dotted lines (E). The overview shows intense staining of CDX2 in tumor and remaining normal colon mucosa (F; asterisk). Examples of squamous differentiation as well as proliferation are shown by immunostaining for CK5/6 (accentuated in central areas; G) and Ki67 (H), respectively.