Table 1.
Gene alteration frequencies in colorectal adenocarcinoma data sets.
| Genes | TCGA Nature 2012 Study | TCGA Pan Cancer Atlas Study | MSKCC 2018 Cancer Cell Study |
|---|---|---|---|
| APC | 76 | 75 | 76 |
| CTNNB1 | 5 | 7 | 8 |
| FBXW7 | 17 | 17 | 13 |
| KRAS | 42 | 42 | 45 |
| PIK3CA | 20 | 28 | 20 |
| TP53 | 53 | 60 | 73 |
| RB1 | 3 | 5 | 3 |
Values indicate the frequency of gene alterations (in percent) in three different data sets according to The Cancer Genome Atlas Program 2012 (TCGA, [16]), TCGA Pan Cancer Atlas Study [17] and Memorial Sloan Kettering Cancer Center Study (MSKCC, [18]). Classical adenoma–carcinoma sequence mutations, such as APC, KRAS and TP53, are highlighted in orange.