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. 2020 Dec 15;10(2):e12039. doi: 10.1002/jev2.12039

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© 2020 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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SyntOFF, a potent C58 derivative. (a) Chemical synthesis scheme of the compound SyntOFF and its intermediary cSyntOFF. Yields are indicated in percentage (b) Activities of 400 µM SyntOFF and cSyntOFF (also further used as negative control) as determined in HTRF assay testing for inhibition of SDC2‐syntenin interaction. Values correspond to mean ± sd of three independent experiments. Statistical analysis was performed using the one‐way analysis of variance (ANOVA) with a Bonferroni posttest (***P < 0.001)