Table 1.
Distribution of HER2 detection in cervical adenocarcinoma and histological subtypes.
| Histological subtypes* | N | IHC 3+ (%) | FISH+ (%) |
|---|---|---|---|
| HPV‐related adenocarcinoma | |||
| Usual type | 111 | 12 (10.8%) | 5 (4.5%) |
| Mucinous, NOS type | 20 | 3(15%) | 2(10%) |
| Stratified mucin‐producing type | 10 | 0 | 0 |
| Villoglandular type | 7 | 0 | 0 |
| Mucinous, intestinal type | 1 | 0 | 0 |
| Signet‐ring cell type | 1 | 1 (100%) | 1 (100%) |
| Non‐HPV‐related adenocarcinoma | |||
| Gastric type | 34 | 5 (14.7%) | 5 (14.7%) |
| Serous type | 4 | 0 | 0 |
| Clear cell type | 4 | 1 (25%) | 0 |
| Endometrioid type | 3 | 0 | 0 |
| Mesonephric type | 1 | 0 | 0 |
| Invasive adenocarcinoma, NOS | 13 | 1 (7.7%) | 0 |
| Total | 209 | 23 (11%) | 13 (6.2%) |
*
The International Endocervical Adenocarcinoma Criteria and Classification (IECC) is applied.