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. 2020 Oct 1;162(1):243–252. doi: 10.1097/j.pain.0000000000002097

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Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 5. — Spontaneous excitatory postsynaptic current frequency is reduced by spike protein or pharmacological antagonism of neuropilin-1 receptor (NRP-1) by EG00229. (A) Representative traces of sEPSC from neurons of the substantia gelatinosa in the superficial dorsal horn (lamina I/II) treated for at least 30 minutes with the indicated conditions. Summary of amplitudes (B) and frequencies (C) of sEPSCs for all groups is shown. Cumulative distribution of the sEPSC amplitude (D) and the interevent interval (E) recorded from cells as indicated. Perfusion of 30 μM EG00229 decreased spontaneous excitatory synaptic transmission (A–E) in lumbar dorsal horn neurons. P values of comparisons between treatments are as indicated; for full statistical analyses, see Table S1, http://links.lww.com/PAIN/B190. sEPSC, spontaneous excitatory postsynaptic current.