Table 1. Demographic characteristics of participants (N = 1121) based on initial presence of CKD.
| Non-CKD | CKD | p value | |
|---|---|---|---|
| (>60 ml/min/1.73m2) | (≤60 ml/min/1.73m2) | ||
| N = 946 | N = 175 | ||
| Demographics | |||
| Age (Median, 25th -75th percentile) | 74 (73–77) | 76(73–78) | 0.002 |
| Male N (%) | 440 (46.5) | 75 (42.9) | 0.37 |
| Black N (%) | 336 (35.5) | 49 (28.0) | 0.05 |
| Lifestyle related | |||
| Smoking at year 3 N (%) | 49 (5.2) | 6 (3.5) | 0.42 |
| Alcohol consumption (>1 drink/ week) N(%) | 516 (54.7) | 82 (46.9) | 0.14 |
| Body Mass Index (Median, 25th -75th percentile) | 26.9 (24.1–29.7) | 27.6 (25.1–30.4) | 0.02 |
| Comorbidities | |||
| Diabetes N (%) | 100 (10.6) | 20 (11.4) | 0.74 |
| Hypertension N (%) | 358 (38.0) | 98 (56.0) | <0.001 |
| Cardiovascular disease N (%) | 182 (19.6) | 46 (26.9) | 0.06 |
| Cerebrovascular disease N (%) | 51 (5.4) | 14 (8.1) | 0.36 |
| Peripheral Vascular Disease N(%) | 98 (10.8) | 25 (14.9) | 0.29 |
| Nerve measurements | |||
| Initial CMAP, median (IQR) | 3.4 (2.0–4.7) | 3.2 (1.7–4.4) | 0.17 |
| Follow up CMAP, median (IQR) | 1.3 (2.3–3.7) | 1.9 (1.1–3.3) | 0.04 |
| Initial NCV, median (IQR) | 44.0 (40.7–47.3) | 43.4 (39.9–46.5) | 0.09 |
| Follow up NCV, median (IQR) | 42.3 (39.1–45.1) | 41.0 (37.9–43.7) | 0.02 |
| Monofilament testing | |||
| Light touch insensitivity, initial | 322 (34.3) | 79 (45.1) | 0.02 |
| Standard touch insensitivity, initial | 64 (6.8) | 13 (7.4) | |
| Light touch insensitivity, follow up | 290 (30.7) | 51 (29.1) | 0.02 |
| Standard touch insensitivity, follow up | 155 (16.4) | 44 (25.1) |
• CMAP = Compound Motor Action Potential, NCV = Nerve Conduction Velocity, CKD = chronic kidney disease, Initial visit = year 2000–01, Follow up visit = year 2007–08