Table 5.1.

Altered ratios of EpFA: diol correlate to disease outcomes

Alzheimers disease (AD) [130]

AD patients with and without type 2 diabetes (T2D) had increased DHET compared to healthy controls. However, there were no effects following adjustments for multiple comparisons.

Arthritis [131]

In synovial fluid of arthritic vs. normal joints, 11,12-DHET and 14,15-DHET were higher in affected joints of people with unilateral osteoarthritis. In addition, these and 8,9-DHET were associated with worse progression over 3.3 years.

Anorexia Nervosa [34, 35]

Ill anorexia nervosa patients have higher DHA diol metabolites 19,20 DiHDPE:EpDPE compared to either recovered AN patients or healthy human subjects, while both ill and recovered AN patients have higher ALA diol metabolites 15,16 DiHODE:EpODE ratios compared to healthy subjects.

Peripheral arterial disease [132]

Increased 8,9 DHET correlated with increased risk of coronary and cerebrovascular events in patients with peripheral arterial disease.

Coronary artery disease [133]

Decreased EETs in patients with obstructive coronary artery disease compared to healthy controls

Depression [134]

In patients with major seasonal depression syndrome, sEH-derived oxylipins (12,13 DiHOME, 7,8- and 19,20 DiHDPE), in addition to other eicosanoids, increased in winter compared to summer-fall, while 14,15 EET and corresponding diol both decreased in the winter.

Preeclampsia [135]

In preeclamptic women 14,15-DHET was higher in urine samples compared to healthy pregnant women.

Vascular dementia [136]

In patients with cognitive impairment, an increase in 9,10- and 12,13 DiHOME: EpOME was associated with poor performance in function but not memory.