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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: Adv Exp Med Biol. 2020;1274:71–99. doi: 10.1007/978-3-030-50621-6_5

Table 5.2.

Clinical development candidates of small molecule sEHI and EpFA mimics

Small molecule sEH inhibitors Clinical Trials
AUDA graphic file with name nihms-1649415-t0005.jpg Clinical trial NCT00654966: Microvessel Tone in patients with heart failure.
Status: Complete. Healthy humans and patients with heart failure challenged with topical urotensin II, a potent vasoconstrictor, and treated with sEHI [74].
TPPU graphic file with name nihms-1649415-t0006.jpg This compound has not been investigated in clinical trials but is the most frequently used compound in preclinical research.
AR9281 graphic file with name nihms-1649415-t0007.jpg Clinical trial NCT00847899: Evaluation of sEHI in Patients with Hypertension and Impaired Glucose Tolerance.
Status: Complete. Single and multiple day testing up to 8 days at doses up to 1.2 g/day (400 mg every 8 h) were well tolerated [129]. Data from Phase II clinical trials not published.
GSK2256294 graphic file with name nihms-1649415-t0008.jpg Clinical trial NCT01762774: A Study to Assess the Safety,
Tolerability, PK and PD of Single and Repeat Doses of GSK2256294 in Healthy Volunteers and Adulate Male Moderately Obese Smokers.
Status: Complete. Doses were well tolerated and attenuated smoking related endothelial dysfunction.
EC1728 (t-TUCB) graphic file with name nihms-1649415-t0009.jpg Clinical trials are in development for companion animals.
EC5026 graphic file with name nihms-1649415-t0010.jpg Clinical trial NCT04228302: Safety, Tolerability, and Pharmacokinetics of Oral EC5026 in Healthy Subjects.
Status: Enrolling
EpFA Mimics Summary of results
CMX020 graphic file with name nihms-1649415-t0011.jpg Clinical trial ACTRN12615000885594: A Study to Evaluate the Safety and Analgesic Efficacy of Oral CMX-020 in Subjects with Symptoms of Sciatica Resulting from Lumbosacral Radiculopathy.
ACTRN12616001435471: A Phase 2 Study to Assess the Efficacy and Safety of CMX-020 in Treating Osteoarthritis.
Status: Phase 1 studies complete. Enrolling for Phase 2.
OMT-28 Structure not disclosed Clinical trial NCT03906799: Study on OMT-28 in Maintenance of Sinus Rhythm in Patients with Persistent Atrial Fibrillation.
Status: Enrolling
Icosabutate graphic file with name nihms-1649415-t0012.jpg Clinical trial NCT04052516: A Phase 2b Study of Icosabutate in Fatty Liver Disease.
Status: Phase 1 studies complete. Enrolling for Phase 2b.
Vascepa (ethyl-EPA) graphic file with name nihms-1649415-t0013.jpg Status: approved for the treatment of hypertriglyceridemia.