Table 4. Rotational thromboelastometry and platelet function test.
| Parameters | Reference range | Day 0 | Day 1 | Day 3 | Day 7 | Day 14 | P value |
|---|---|---|---|---|---|---|---|
| ROTEM—INTEM | |||||||
| Clotting time (sec) | 100–240 | ||||||
| All patients | 164 (155–184) | 160 (156–191) | 173 (159–196) | 171 (157–193) | 163 (153–190) | 0.300a | |
| SOFA≤10 | 165 (141–180) | 157 (153–168) | 161 (142–180) | 172 (162–193) | 171 (148–188) | 0.035b | |
| SOFA >10 | 159 (157–184) | 176 (156–194) | 184 (172–214)# | 169 (152–185) | 157 (153–194) | 0.378c | |
| Clot formation time (sec) | 30–110 | ||||||
| All patients | 48 (46–59) | 47 (42–57) | 44 (39–55) | 42 (39–48) | 41 (34–47) | 0.096a | |
| SOFA≤10 | 48 (45–55) | 46 (41–52) | 40 (35–47) | 42 (37–47) | 34 (29–49) | 0.026b | |
| SOFA >10 | 53 (47–62) | 51 (43–63)# | 52 (45–62)# | 43 (40–61) | 43 (39–46) | 0.567c | |
| Maximum clot firmness (mm) | 50–72 | ||||||
| All patients | 70 (67–72) | 71 (69–73)* | 73 (70–76) | 75 (70–78)* | 76 (69–79)* | <0.001a | |
| SOFA≤10 | 70 (68–72) | 72 (70–74) | 74 (72–76) | 75 (70–79) | 78 (70–80) | 0.312b | |
| SOFA >10 | 70 (66–73) | 71 (67–73) | 72 (70–76) | 75 (71–77) | 75 (69–78) | 0.914c | |
| Maximum lysis (%) | £15 | ||||||
| All patients | 10 (6–12) | 8 (5–10)* | 6 (3–9)* | 3 (2–6)* | 4 (2–6)* | <0.001a | |
| SOFA≤10 | 11 (6–13) | 8 (4–10) | 7 (6–9) | 5 (2–6) | 5 (2–6) | 0.223b | |
| SOFA >10 | 9 (6–12) | 8 (5–11) | 3 (2–7) | 2 (1–3)# | 3 (2–7) | 0.004c | |
| ROTEM—EXTEM | |||||||
| Clotting time (sec) | 38–79 | ||||||
| All patients | 72 (66–79) | 73 (66–88) | 78 (70–84)* | 73 (62–88) | 72 (61–80) | 0.013a | |
| SOFA≤10 | 76 (71–81) | 75 (67–94) | 76 (68–78) | 74 (68–81) | 78 (61–83) | 0.486b | |
| SOFA >10 | 68 (66–71) | 72 (64–75) | 85 (77–94)# | 68 (61–89) | 67 (65–80) | 0.001c | |
| Clot formation time (sec) | 34–159 | ||||||
| All patients | 54 (44–61) | 56 (45–64) | 48 (41–63) | 49 (41–57) | 47 (41–56) | 0.123a | |
| SOFA≤10 | 53 (44–61) | 52 (43–62) | 45 (40–64) | 46 (37–56) | 38 (31–59) | 0.124b | |
| SOFA >10 | 54 (50–64) | 60 (45–73) | 56 (47–63) | 53 (45–62) | 51 (44–55) | 0.839c | |
| Maximum clot firmness (mm) | 50–72 | ||||||
| All patients | 73 (69–74) | 73 (70–75) | 75 (71–77) | 74 (70–79)* | 74 (69–79) | <0.001a | |
| SOFA≤10 | 73 (70–75) | 74 (71–76) | 76 (71–77) | 75 (70–79) | 75 (69–80) | 0.344b | |
| SOFA >10 | 71 (68–73) | 72 (68–73) | 73 (71–80) | 74 (72–78) | 74 (69–78) | 0.415c | |
| Maximum lysis (%) | £15 | ||||||
| All patients | 10 (7–12) | 9 (6–13) | 8 (5–10)* | 8 (3–11) | 7 (5–11) | 0.006a | |
| SOFA≤10 | 10 (8–12) | 9 (6–11) | 8 (6–9) | 8 (4–12) | 7 (4–11) | 0.863b | |
| SOFA >10 | 9 (6–15) | 10 (7–13) | 8 (4–11) | 4 (3–10) | 8 (5–11) | 0.617c | |
| ROTEM—FIBTEM | |||||||
| Maximum clot firmness (mm) | 9–25 | ||||||
| All patients | 36 (32–38) | 37 (30–40) | 41(30–44) | 37 (31–45) | 35 (28–47) | 0.080a | |
| SOFA≤10 | 37 (30–41) | 37 (30–41) | 40 (28–43) | 42 (31–46) | 32 (27–49) | 0.836b | |
| SOFA >10 | 36 (33–38) | 36 (31–40) | 42 (36–46) | 37 (32–42) | 38 (31–43) | 0.050c | |
| PLATELET function test | |||||||
| ARATEM test (sec) | 70–153 | ||||||
| All patients | 79 (54–110) | 87 (58–113) | 81 (62–112) | 114 (89–124)* | 110 (83–154)* | 0.014a | |
| SOFA≤10 | 79 (53–108) | 88 (65–112) | 85 (71–110) | 121 (115–154) | 140 (85–182) | 0.068b | |
| SOFA >10 | 79 (54–122) | 76 (36–113) | 62 (43–112) | 95 (65–110)# | 109 (83–116) | 0.161c | |
| ADPTEM test (sec) | 56–139 | ||||||
| All patients | 96 (65–111) | 105 (72–128) | 92 (76–117) | 127 (86–138) | 112 (67–134) | 0.004a | |
| SOFA≤10 | 105 (83–126) | 105 (89–127) | 92 (78–116) | 135 (115–148) | 126 (73–159) | 0.024b | |
| SOFA >10 | 85 (56–107) | 106 (51–135) | 91 (61–118) | 82 (63–129)# | 96 (67–116) | 0.121c |
Values represent median (IQR). SOFA: sequential organ failure assessment score. P values were calculated with the use of generalized estimating equations (GEE): (a): time effect, (b): group effect and (c): time-group interaction. Pairwise comparisons significant at the 0.05 level:
(*): time effect—pooled patients: each time point vs. Day 0.
(#): between group comparisons (group SOFA>10 vs. group SOFA ≤10) at each time point.