TABLE 3.
Kidney function and immunopathology at time of biopsy
| Variables | cAMR (n = 49) | Control (n = 49) | P | |
|---|---|---|---|---|
| DSA | Class I MFIsum | 3917 ± 5718 (n = 24) | 2486 ± 4545 (n = 22) | 0.36 |
| Class II MFIsum | 19,890 ± 22,445 (n = 40) | 4509 ± 5303 (n = 37) | <0.001 | |
| Immunodominant MFImax | 11,159 ± 9,298 | 3954 ± 5469 | <0.001 | |
| Kidney function | Scr (mg/dl) | 2.2 ± 1.6 | 1.4 ± 0.5 | <0.001 |
| eGFR (ml/min) | 38.9 ± 17.8 | 56.4 ± 20.0 | <0.001 | |
| UPC (g/g) | 1.6 ± 1.8 | 0.2 ± 0.2 | <0.001 | |
| Pathology | i score (0–3) | 0.26 ± 0.63 | 0.02 ± 0.14 | 0.01 |
| t score (0–3) | 0 | 0 | ||
| v score (0–3) | 0.02 ± 0.14 | 0 | ||
| MVI ptc + g (0–6) | 2.90 ± 1.01 | 0 | ||
| ptc (0–3) | 1.20 ± 0.68 | 0 | ||
| g (0–3) | 1.61 ± 0.84 | 0 | ||
| C4d (0–3) | 1.42 ± 1.37 | 0 | ||
| cg (0–3) | 1.98 ± 0.95 | 0.04 ± 0.20 | <0.001 | |
| ci+ct+cg+cv (0–12) | 5.73 ± 2.30 | 2.0 ± 2.14 | <0.001 |
DSA, donor-specific antibody; eGFR, estimated glomerular filtration rate; MFI, mean fluorescence intensity; MVI, microvascular inflammation; UPC, urine protein to creatinine ratio.