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. 2020 Dec 11;99(50):e23563. doi: 10.1097/MD.0000000000023563

Table 3.

GO and KEGG pathway enrichment analysis of DEGs in the most significant module.

Category Term Pathway description Count in gene set Adjusted P
BP term GO:0009611 response to wounding 16 1.06E-11
BP term GO:0030193 regulation of blood coagulation 8 2.04E-10
BP term GO:0050818 regulation of coagulation 8 3.64E-10
BP term GO:0032101 regulation of response to external stimulus 10 3.43E-09
BP term GO:0042060 wound healing 10 1.43E-08
BP term GO:0006953 acute-phase response 7 1.91E-08
BP term GO:0030195 negative regulation of blood coagulation 6 8.61E-08
BP term GO:0002526 acute inflammatory response 8 7.76E-08
BP term GO:0050817 coagulation 8 9.16E-08
BP term GO:0007596 blood coagulation 8 9.16E-08
BP term GO:0050819 negative regulation of coagulation 6 1.17E-07
BP term GO:0007599 hemostasis 8 1.12E-07
CC term GO:0005615 extracellular space 29 5.54E-20
CC term GO:0005576 extracellular region 22 1.77E-19
CC term GO:0044421 extracellular region part 22 1.29E-16
MF term GO:0004857 enzyme inhibitor activity 14 3.38E-13
MF term GO:0004866 endopeptidase inhibitor activity 12 2.47E-13
MF term GO:0030414 peptidase inhibitor activity 12 2.99E-13
KEGG pathway hsa04610 Complement and coagulation cascades 10 4.97E-14

BP = biological process, CC = cellular component, DEGs = differentially expressed genes, GO = Gene Ontology, KEGG = Kyoto Encyclopedia of Genes and Genomes, MF = molecular function.