Fig 6. Ifit2 deficiency impairs CD45⁺ leukocyte migration into the CNS at day 5 and 7 post infection.

Brains from WT and Ifit2^-/- mice infected with RSA59 were harvested at days 3, 5, and 7 p.i. for flowcytometric analysis. Purple colour denotes WT and green represents Ifit2^-/- mice. Panel A shows representative flow cytometry plots at day 5 and 7 p.i., indicating percentages of CD45^hiand CD45^lo cells in brains after gating on live cells. Absolute numbers of CD45^hi cells are graphically represented across timepoints (Panel B) and in between WT and Ifit2^-/- groups for day 5 p.i., and day 7 p.i. (Panel C) to better represent respective statistics. Graphs represent n = 14–20 mice from 3 separate experiments. Asterix (*) represents differences that are statistically significant by Student’s unpaired t-test analysis. (*P<0.05, **P<0.01).