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. 2020 Dec 9:1–12. doi: 10.1080/07391102.2020.1858164

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Figure 1. — Sequence alignment of the main protease (Mpro) from SARS CoV-1 and SARS CoV-2 (Tahir Ul Qamar et al., 2020). The amino acid sequence alignment of Mpro from SARS CoV-1 (PDB ID 1UJ1) and SARS CoV-2 (PDB ID 6LU7) was performed using CLUSTALW (1.83) multiple sequence alignment program. The main protease from the two coronaviruses possesses Domain I (highlighted with green), Domain II (highlighted with turquoise), Domain III (highlighted in yellow) and a connecting loop (highlighted with grey). The symbols represent identical residues (*), conserved substitutions (:) and semi-conserved substitutions (.), respectively. The different amino acid residues are shown inside red-colored rectangular boxes.