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. 2020 Dec 16;86:153440. doi: 10.1016/j.phymed.2020.153440

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© 2020 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Dose-dependent inhibition of MERS-CoV infection by lycorine. (A) Chemical structure of lycorine. (B) The confocal microscope images showed cell nuclei (red) and MERS-CoV spike (S) protein (green) at the indicated lycorine concentration or 8.3 μM remdesivir (RDV) after MERS-CoV infection. Scale bar = 100 μM. (C) Dose-response curve analysis by immunofluorescence staining was used to measure the antiviral effect of lycorine. Blue circles represent inhibition of SARS-CoV-2 infection (%) by lycorine, the red squares represent cell viability (%) by lycorine and black circles represent inhibition of SARS-CoV-2 infection (%) by remdesivir. Data are representative of duplicate experiments and are presented as the mean ± SEM. (D) Lycorine (6 μM) or chloroquine (40 μM, positive control) inhibition of plaque formation was determined by plaque assay at 3 days post MERS-CoV (20 PFU) infection.