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. 2020 Dec 16;86:153440. doi: 10.1016/j.phymed.2020.153440

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© 2020 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Dose-dependent inhibition of SARS-CoV and SARS-CoV-2 infection by lycorine. (A and B) The confocal microscope images showed SARS-CoV spike (S) protein (green) and cell nuclei (red) at the indicated lycorine concentration or 8.3 μM remdesivir (RDV) after SARS-CoV infection (A) and SARS-CoV-2 nucleocapsid (N) protein (green) and nuclei (red) at the indicated lycorine concentration or 5 μM remdesivir (RDV) after SARS-CoV-2 infection (B). Scale bar = 100 μM. (C and D) Dose-response curve analysis by immunofluorescence staining was used to measure anti-SARS-CoV (C) and anti-SARS-CoV-2 (D) infection effects of lycorine. Blue circles represent inhibition of viral infection (%) and red squares represent cell viability (%) by lycorine. Black circles represent inhibition of SARS-CoV-2 infection (%) by remdesivir. Data are representative of duplicate independent experiments and are presented as the mean ± SEM. (E and F) lycorine (2 μM) or remdesivir (15 μM) inhibition of plaque formation was determined by plaque assay at 3 days post SARS-CoV (70 PFU) infection (E) or at 4 days post SARS-CoV-2 (50 PFU) infection (F).