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Schematic diagram of chemoembolizing arsenic trioxide (ATO) microcrystal-loaded microsphere. ATO crystal (36.43 ± 18.32 μm; data: mean ± SD) was micronized to ATO microcrystal (1.58 ± 0.42 μm), which was encapsulated with PLGA to generate ATO-microcrystal loaded microsphere (AM) (4.51 ± 1.77 μm). Chemoembolizing AM on HCC mice model significantly inhibited tumor growth.
