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. 2020 Dec 2;12:614690. doi: 10.3389/fnagi.2020.614690

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Copyright © 2020 Wong, Frost and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GSMPs pull the strings of γ-secretase activity. GSMPs act as a guiding hand to modulate γ-secretase activity in response to cellular and environmental cues such as hypoxia, inflammation, ER stress, and aging.