Figure 2.

Schematic representation of CAR T cell control mechanisms. A. Tuning the affinity of the scFv to tumor antigen and drug-induced inhibition of CAR T cell signaling by dasatinib. B. Split-CAR signaling by adaptors or drug-induced dimerization. HIF-driven CAR expression is regulated by hypoxic environment i.e. tumor microenvironment. The suicide gene iCasp9 can be activated by a dimerizable drug to kill CAR T cells. C. CAR T cells can have autonomous regulation in the killing of targets based on cell surface protein expression by cancerous and healthy cells. Figure created with Biorender.