Table 3.

Hazard Ratio (HR) with 95 % Confidence Intervals (CI) in all MPN and subdivided by MPN subtype. Estimated from flexible parametric models, adjusting for age group (18–49, 50–59, 60–69, 70–79, and 80 years and older), sex and calendar period (1992–1998, 1999–2005, and 2006–2013).

Outcome	HR all MPN (95%CI)	PV HR (95%CI)	ET HR (95%CI)	PMF HR (95%CI)
Combined outcomes
Any infections	2.0 (1.9–2.0)	1.7 (1.6–1.8)	1.7 (1.5–1.8)	3.7 (3.2–4.1)
Bacterial infections	1.9 (1.8–2.0)	1.7 (1.6–1.8)	1.6 (1.5–1.8)	3.4 (3.0–3.9)
Viral infections	2.1 (1.9–2.3)	1.8 (1.5–2.1)	1.7 (1.4–2.1)	5.2 (3.8–7.1)
Fungal infections	2.9 (2.5–3.5)	2.6 (1.9–3.4)	2.2 (1.6–3.0)	8.0 (4.9–13.3)
Infection type
Sepsis	2.6 (2.4–2.9)	2.1 (1.8–2.5)	2.0 (1.6–4.7)	6.2 (4.8–8.0)
Pneumonia	2.0 (1.9–2.1)	1.8 (1.6–2.0)	1.6 (1.4–1.8)	3.8 (3.2–4.6)
Urinary tract infections	1.6 (1.5–1.7)	1.5 (1.4–1.7)	1.5 (1.3–1.6)	2.2 (1.8–2.8)
Skin and soft tissue infections	2.1 (1.8–2.4)	1.8 (1.4–2.3)	1.6 (1.2–2.0)	4.9 (3.2–7.4)
Gastrointestinal infections	2.3 (2.1–2.6)	2.3 (1.9–2.8)	1.7 (1.3–2.0)	4.8 (3.4–6.8)
Infectious agent
Streptococci excl. pneumococci	2.3 (1.7–3.1)	2.4 (1.5–3.8)	1.1 (0.6–2.0)	8.7 (4.0–19.1)
Staphylococci	2.4 (2.0–2.8)	1.6 (1.2–2.1)	1.8 (1.3–2.4)	5.5 (3.6–8.6)
Escherichia coli	1.9 (1.6–2.2)	1.8 (1.4–2.4)	1.7 (1.2–2.2)	3.7 (2.1–6.5)
Varicella zoster	2.0 (1.4–2.8)	0.98 (0.5–2.0)	2.5 (1.4–4.5)	7.3 (2.9–18.3)

HR Hazard Ratio, CI Confidence Interval MPN myeloproliferative neoplasms, PV polycythemia vera, ET essential thrombocythemia and PMF primary myelofibrosis