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Forest plot of hazard ratios for BB exposure in each of the validation cohorts and for the total validation (meta-analysis). The optimal PRP score cutoff from the derivation dataset was tested in Cox proportional hazards models adjusted for MAGGIC43 and BB propensity score44, 45. Low and high PRP indicate values above or below threshold (30th percentile of the derivation set). BB = Beta Blocker; PRP = polygenic response predictor
