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. 2020 Dec 2;7:577460. doi: 10.3389/fmolb.2020.577460

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Copyright © 2020 Shao, Dong, Zhang, Wu and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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YTH domain family (YTHDF) 2 expression has significant correlations with infiltration of immune cells and macrophage polarization in liver hepatocellular carcinoma (LIHC). (A) YTHDF2 expression was significantly positively related to infiltration of B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils, and dendritic cells in LIHC. (B–D) Scatterplots of correlations between YTHDF2 expression and gene markers of monocytes (B), TAMs (C), M1 macrophages (D), and M2 macrophages (E) in LIHC. Monocyte markers: CD86 and CSF1R. TAM markers: CCL2, CD68, and IL10. M1 macrophages markers: NOS2, IRF5, and PTGS2. M2 macrophages markers: CD163, VSIG4, and MS4A4A.