TABLE 3.

Cox regression analysis the association between clinicopathological variables and overall survival.

Parameter	TCGA-LIHC Univariate analysis				ICGC-LIRI Univariate analysis
	OS		DFS		OS
	HR(95%CI)	p-value	HR(95%CI)	p-value	HR(95%CI)	p-value
Age	1.01 (0.99–1.02)	0.59	1.00 (0.98–10.1)	0.59	1.00 (0.97–1.03)	0.90
Gender	0.78 (0.49–1.25)	0.30	0.72 (0.48–1.06)	0.09	0.52(0.28–0.97)	0.04
Grade	1.02 (0.75–1.39)	0.91	1.15 (0.89–1.47)	0.28	NA
Stage	1.86 (1.46–2.39)	0.00	1.73 (1.41–2.13)	1.40e-07	2.15(1.49–3.11)	4.13e-05
T classification	1.80 (1.43–2.27)	0.00	1.67 (1.37–2.02)	2.27e-07	NA
M classification	3.85 (1.21–12.28)	0.02	4.56 (1.43–14.57)	0.01	NA
N classification	2.02 (0.49–8.28)	0.33	1.34 (0.33–5.44)	0.68	NA
YTHDF2	2.05 (1.39–3.04)	0.00	1.72 (1.23–2.40)	0.00	1.46 (1.11–1.93)	0.00

OS, overall survival; DFS, disease-free survival; HR, hazard ratio; NA, not available. Bold values indicate p < 0.05. p < 0.05 was considered statistically significant.