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. 2020 Dec 15;10:21969. doi: 10.1038/s41598-020-77714-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MiR-125b-2 knockout increased HFD-induced obesity. (A) The body weight (BW) between WT and KO mice fed a ND was not significantly different (P > 0.05). (B) MiR-125b-2 knockout promotes HFD-induced obesity in male mice. (C) Feed intake between WT and KO mice fed ND and HFD. (D) Body imaging results of body fat distribution in WT and KO mice fed ND or HFD. (E) The body fat and body muscle content in WT and KO mice in the ND group. (F) The body fat and body muscle content in WT and KO mice in the HFD group. (G) The serum HDL-L, LDL-L, TC, GLU, and TG contents of WT and KO mice fed ND or (H) HFD. Data are presented as mean ± SE (*P < 0.05, **P < 0.01, n = 8 mice per group).