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. 2020 Dec 15;10:21989. doi: 10.1038/s41598-020-78971-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bacterial population structure at genus or species level. Heat map of the relative abundance of bacteria in supragingival plaque and saliva, at genus or species level, at each time point. T0 time point prior to placement of fixed orthodontic appliance, T1 time point approximately 6 months after the start of orthodontic treatment, T2 time point after appliance removal (average, 40 months after placement).