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. 2020 Dec 15;10:22011. doi: 10.1038/s41598-020-78886-y

Figure 2.

Figure 2

Effects of ML335 and BL1249 on BAL fluid cytokine concentrations (AF): HO exposure increased IL-6, IP-10, CCL-2, TNF-α, and IL-10 concentrations, but not MIP-1α. Once-daily i.t. treatment with ML335 or BL1249 decreased HO-induced IL-6 and IP-10 levels, but not CCL-2, TNF-α or IL-10. Data are represented as Box-Whisker plots with medians, 1st and 3rd quartiles, and max and min values; n = 5–9; ^compared to mice exposed to room air and treated with a vehicle control (no drugs), *compared to HO exposed mice; p ≤ 0.05.