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. 2020 Dec 15;10:22011. doi: 10.1038/s41598-020-78886-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TREK-1 activation with ML335 and BL1249 regulates cytokine secretion from primary mouse AT2 cells: HO exposure increased IL-6 and CCL-2 secretion, which were inhibited by concomitant treatment with ML335 or BL1249 (A, C). In contrast, IP-10, TNF-α, MIP-1α and IL-10 levels were not affected by TREK-1 activation in room air- or HO-exposed AT2 cells (B,D,E,F). Data are represented as Box-Whisker plots with medians, 1st and 3rd quartiles, and max and min values; n = 5–9; ^compared to cells treated with a vehicle control and exposed to room air (no drugs), *compared to HO exposed cells; p ≤ 0.05.