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. 2020 Dec 15;10:22011. doi: 10.1038/s41598-020-78886-y

Figure 4.

Figure 4

TREK-1 activation with ML335 and BL1249 regulates cytokine secretion from primary human alveolar epithelial cells (HAEC): HO exposure increased secretion of IL-6, IP-10, CCL-2 and IL-10, and this effect was counteracted by ML335 or BL1249 (A,B,C,F). In contrast, TNF-α and MIP-1α levels were not affected by TREK-1 activation in room air- or HO-exposed HAECs (D,E). Data are represented as Box-Whisker plots with medians, 1st and 3rd quartiles, and max and min values; n = 4–8; ^compared to cells treated with a vehicle control and exposed to room air (no drugs), *compared to HO exposed cells; p ≤ 0.05.