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. 2020 Dec 15;10:22011. doi: 10.1038/s41598-020-78886-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ML335 and BL1249 activate TREK-1 currents in primary mouse AT2 cells: Summary of n = 4–5 independent FLIPR curves (means ± SEM) showing that the TREK-1 activating compounds ML335 or BL1249 induce TREK-1 specific K⁺ currents under both room air and HO conditions (A,B). In both room air and HO-treated cells, baseline background K⁺ currents were observed (No drug). *compared to vehicle control (No drug) at room air, ^compared to vehicle control (No drug) after HO exposure; p ≤ 0.05, n = 4–5, individual experiments were run in triplicates.