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. 2020 Dec 15;10:22011. doi: 10.1038/s41598-020-78886-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TREK-1 activation decreases intracellular Ca²⁺ (iCa) concentrations in HO-exposed primary mouse AT2 cells: (A,B) Representative curves of Ca²⁺-sensitive Fluo-4 assays showing that HO-exposed AT2 cells contain higher iCa concentrations than RA-exposed cells, as indicated by an increase in fluorescence values (purple arrows on Y-axes). TREK-1 activation with BL1249 has no effect on iCa concentrations in RA-exposed cells, but decreases iCa levels in HO-exposed cells (*BL1249 compared to no drug/vehicle control, p ≤ 0.05). A summary of n = 6 independent experiments is shown in C; data are represented as Box-Whisker plots with medians, 1st and 3rd quartiles, and max and min values; ^compared to room air exposed AT2 cells; p ≤ 0.05, individual experiments were run in triplicates.