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. 2020 Dec 15;10:22011. doi: 10.1038/s41598-020-78886-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of voltage-gated Ca²⁺ channel (Ca_V) inhibition on cytokine secretion from primary mouse AT2 cells: HO exposure increased IL-6 (A) and CCL-2 (B) secretion compared to RA-treated cells. Inhibition of N- and P/Q-type Ca_V channels with ω-conotoxin MVIIC or L-type Ca_V channels with nifedipine revealed that IL-6 secretion occurred independently of Ca_V channel activity, whereas CCL-2 secretion was dependent on L-type Ca_V channels (inhibited by nifedipine) but not N- and P/Q-type channels (lack of ω-conotoxin MVIIC effect). Data are represented as Box-Whisker plots with medians, 1st and 3rd quartiles, and max and min values; n = 3–6; ^compared to cells treated with a vehicle control and exposed to room air (No drugs), *compared to HO exposed cells; p ≤ 0.05.