Table 1.

Relative concentration of significantly changed metabolites in MDA-MB-231 cultured at pH 6.5 (mean ± SD).

No	Name	Retention time (s)	VIP	P value	Fold change (SA/NP)	NP_mean	SA_mean
1	Inositol	1829.80	8.59	2.37E−05	0.69	1.44 ± 0.13E + 08	9.93 ± 0.74E + 07
2	Lactate	419.75	7.87	4.65E−05	0.66	1.13 ± 0.11E + 08	7.46 ± 0.82E + 07
3	Proline	772.96	6.55	5.19E−03	1.50	6.47 ± 0.21E + 07	9.67 ± 2.19E + 07
4	Oxoproline	1109.47	5.55	1.29E−03	0.68	6.60 ± 0.79E + 07	4.48 ± 0.86E + 07
5	Alanine	474.73	3.70	8.44E−08	0.38	1.27 ± 0.07E + 07	4.88 ± 1.23E + 06
6	Threonine	912.18	2.65	8.27E−07	0.51	8.38 ± 0.56E + 06	4.29 ± 0.74E + 06
7	Glutamic acid	1254.96	2.62	6.09E−10	0.16	4.61 ± 0.39E + 06	7.26 ± 1.59E + 05
8	Glycerol-3-P	1441.45	1.91	2.10E−10	2.06	1.94 ± 0.16E + 06	3.99 ± 0.12E + 06
9	Palmitate acid	1781.48	1.56	1.53E−03	1.51	3.30 ± 0.51E + 06	4.99 ± 0.81E + 06
10	Citric acid	1512.52	1.45	1.20E−08	0.50	2.41 ± 0.12E + 06	1.21 ± 0.13E + 06
11	Phenylalanine	1144.82	1.44	3.01E−04	2.35	9.96 ± 1.63E + 05	2.34 ± 0.59E + 06
12	Stearic acid	1993.75	1.30	1.98E−04	1.49	2.22 ± 0.29E + 06	3.30 ± 0.37E + 06
13	Tyrosine	1653.09	1.25	1.08E−03	0.50	2.13 ± 0.44E + 06	1.06 ± 0.38E + 06
14	N-Acetyl-L-Glutamic acid	1464.95	1.08	3.54E−06	0.54	1.49 ± 0.05E + 06	8.06 ± 1.76E + 05
15	Putrescine	1403.13	1.07	5.42E−04	0.58	1.81 ± 0.20E + 06	1.05 ± 0.32E + 06
16	Aspartic acid	1112.58	1.02	4.51E−05	0.12	7.27 ± 1.92E + 05	8.97 ± 2.22E + 04