Table 2.

Relative concentration of significantly changed metabolites in MDA-MB-231 cultured at pH 6.5 with 10 mmol/L lactate (mean + SD).

No	Name	Retention time (s)	VIP	P value	Fold change (LA/NP)	NP_mean	LA_mean
1	Inositol	1829.80	11.55	3.11E−06	0.60	1.44 ± 0.13E + 08	8.65 ± 0.80E + 07
2	Oxoproline	1109.47	3.92	3.57E−02	0.84	6.60 ± 0.79E + 07	5.56 ± 0.68E + 07
3	Alanine	474.73	3.36	4.97E−04	0.58	1.27 ± 0.68E + 07	7.34 ± 2.52E + 06
4	Isoleucine	768.53	3.20	2.50E−03	0.72	1.89 ± 0.17E + 07	1.36 ± 0.27E + 07
5	Glutamic acid	1254.96	3.10	3.69E−10	0.14	4.61 ± 0.39E + 06	6.54 ± 1.19E + 05
6	Threonine	912.18	2.88	6.95E−05	0.55	8.38 ± 0.56E + 06	4.62 ± 1.30E + 06
7	Valine	645.57	2.00	4.86E−02	0.78	1.26 ± 0.20E + 07	9.79 ± 2.30E + 06
8	Taurine	1307.83	1.97	6.78E−03	0.19	2.61 ± 1.31E + 06	4.83 ± 3.69E + 05
9	Tyrosine	1653.09	1.94	7.69E−06	0.23	2.13 ± 0.44E + 06	4.84 ± 1.95E + 05
10	Putrescine	1403.13	1.57	1.77E−05	0.40	1.81 ± 0.20E + 06	7.25 ± 2.85E + 05
11	Phenylalanine	1144.82	1.54	4.52E−05	2.05	9.96 ± 1.63E + 05	2.04 ± 0.34E + 06
12	Palmitic acid	1781.48	1.38	9.13E−03	1.33	3.30 ± 0.51E + 06	4.38 ± 0.64E + 06
13	Citric acid	1512.52	1.34	3.90E−05	0.66	2.41 ± 0.12E + 06	1.60 ± 0.26E + 06
14	Urea	736.71	1.25	2.95E−05	0.28	9.80 ± 1.24E + 05	2.78 ± 2.05E + 05
15	Glycerol-3-P	1946.17	1.22	5.37E−05	0.76	2.75 ± 0.23E + 06	2.08 ± 0.09E + 06
16	Gluconic acid	1682.51	1.20	7.68E−07	1.52	1.17 ± 0.10E + 06	1.78 ± 0.10E + 06
17	Glycine	786.86	1.19	2.31E−02	0.83	4.84 ± 0.16E + 06	4.01 ± 0.74E + 06
18	Lysine	1634.06	1.19	4.30E−05	0.21	7.96 ± 2.07E + 05	1.66 ± 0.87E + 05
19	Serine	873.10	1.09	1.44E−03	0.56	1.36 ± 0.12E + 06	7.65 ± 3.13E + 05