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. 2020 Dec 15;10:21950. doi: 10.1038/s41598-020-78932-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RNA-sequencing identifies transcriptional changes between fibroblasts and iPSCs samples. (A) Flowchart of the RNA-Seq and downstream analysis. (B) Heatmap analysis for the genes expression levels that showed unique cluster for iPS cell lines and another unique cluster for fibroblasts. (C) Two dimensional PCA analysis that shows similarities among fibroblasts and iPS cells; dots highlighted in red and blue represent fibroblasts and iPSCs gene sets; respectively. (D) Venn diagram of differentially expressed genes (FDR < 0.01, FC > 2) in the PD iPS cell lines (ID-PD, A53T-PD1 and A53T-PD2) versus control iPS cell line. “0” refers to IMR90-1.