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. 2020 Dec 2;11:605644. doi: 10.3389/fimmu.2020.605644

Figure 1.

Figure 1

Human and experimental dermatophytosis (A, B). Superficial mild inflammatory infections in humans by M. canis (A) tinea corporis and (B) tinea capitis by M. canis (C–F). Inflammatory human dermatophytosis (C): inflammatory tinea capitis (Kerion de Celsi) by T. mentagrophytes and (D) deep infection of the scalp by M. canis (ref. 106) showing hyphae in dermis (E) stained with PAS-hematoxylin or (F) Grocott-Gomori’s methenamine silver (GMS) staining (200x magnification) (G–J). Experimental dermatophytosis after epicutaneous infection of (G, H) wild-type (WT) or (I, J) IL-17RA-deficient C57BL/6 mice with M. canis (8 days post-infection) (ref. 51) (G). Mild inflammatory lesions and (H) histopathology showing PAS-positive hyphae invading the stratum corneum and hair follicles in WT (I). Highly inflammatory lesions and (J) histopathology showing extensive superficial fungal proliferation in IL-17RA-deficient mice. Arrows: M. canis hyphae. Asterix: inflammatory reaction (400x magnification). All images are property of Chiapello’s lab.