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. 2020 Dec 2;10:597672. doi: 10.3389/fonc.2020.597672

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Copyright © 2020 Chen, Shen, Zhao, Wang, Shan, Li, Xu, Chen, Liu and Cao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Magnolol abolished transforming growth factor-β1 (TGF-β1)-Induced epithelial-mesenchymal-transition (EMT) amd phosphorylation of Smad2/3 in vitro. (A) Morphological changes in Panc-1 and AsPC-1 cells after culture with Magnolol or TGF-β1. (B) Evaluation of cell morphology for Panc-1and AsPC-1 treated with Magnolol or TGF-β1. (C, E) Western blot results of E-cadherin, N-cadherin, Vimentin, p-Smad2/3, Smad2/3 in Panc-1or AsPC-1 treated with Magnolol or TGF-β1. (D, F) Histograms show the changes of relative expression of E-cadherin, N-cadherin, Vimentin, p-Smad2/3, Smad2/3 in Panc-1or AsPC-1 treated with Magnolol or TGF-β1. *P < 0.05.