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. 2020 Dec 2;13:587815. doi: 10.3389/fnmol.2020.587815

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Copyright © 2020 Dupré, Derambure, Le Dieu-Lugon, Hauchecorne, Detroussel, Gonzalez, Marret and Leroux.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified schematic representation of seIPA-path “super pathway of cholesterol biosynthesis” significantly repressed in P5 brain 12 h after HI (p = 6.3E-12, z-score = –3.37). Repressed genes figure in bold characters. Numbers (Arabic and roman) figure intermediate metabolites in two alternate biosynthesis routes. Values in parentheses indicate fold change inhibition at 12 h after HI. Acat3 enzyme coding gene (in bold italics) does not exist in Human, thus IPA^§ release proposed the human homolog Acat2. Arrows indicate the enzyme’s multiple sites of implication. Large Arrow pointed toward Nsdhl, the only gene in this pathway affected by HI at P10.