TABLE 2.
GO-terms extracted from the series of genes affected after HI (Inductions and repressions) at P5 or P10, using DAVID§ and Revigo§.
| P5 | P10 | ||||||||
| GO-term | Description | Type | N* | P-value | Kinetics (n#) | N | P-value | Kinetics (n) | Genes in common |
| GO:0050729 | Positive regulation of inflammatory response | BP | 18 | 7,36E-09 | Lasting | 18 | 3,49E-06 | Lasting | 16 |
| GO:0006954 | Inflammatory response | BP | 45 | 1,71E-07 | Lasting | 51 | 4,16E-07 | Late (2) | 28 |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | BP | 69 | 7,03E-07 | Early (1) | 102 | 2,40E-07 | Early (3) | 37 |
| GO:0002376 | Immune system process | BP | 41 | 1,12E-06 | Late (1) | 61 | 1,07E-11 | Late (2) | 25 |
| GO:0006351 | Transcription, DNA-templated | BP | 116 | 2,18E-06 | Early (1) | 164 | 4,04E-06 | Early (2) | 54 |
| GO:0006915 | Apoptotic process | BP | 47 | 8,37E-06 | Early (1) | 65 | 2,22E-04 | Lasting$ | 28 |
| GO:0034097 | Response to cytokine | BP | 19 | 1,00E-05 | Early (1) | 20 | 1,03E-04 | Late (2) | 13 |
| GO:0001525 | Angiogenesis | BP | 38 | 2,13E-05 | Early (3) | 38 | 6,94E-05 | Late (2) | 23 |
| GO:0030593 | Neutrophil chemotaxis | BP | 15 | 2,41E-05 | Late (2) | 17 | 5,83E-05 | Late (2) | 14 |
| GO:0071347 | Cellular response to interleukin-1 | BP | 14 | 2,01E-03 | 18 | 8,49E-05 | Late (2) | 13 | |
| GO:0005634 | Nucleus | CC | 285 | 3,15E-07 | Early (1) | 634 | 1,06E-08 | Lasting | 130 |
| GO:0005615 | Extracellular space | CC | 155 | 6,20E-05 | Late (1) | 136 | 3,43E-09 | Lasting | 50 |
| GO:0009986 | Cell surface | CC | 64 | 4,18E-04 | Transient (2) | 74 | 2,09E-06 | Lasting | 31 |
| GO:0005737 | Cytoplasm | CC | 395 | 5,76E-04 | Early (1) | 495 | 9,26E-09 | Lasting | 171 |
| GO:0045121 | Membrane raft | CC | 28 | 3,40E-03 | 39 | 9,93E-07 | Late (1) | 18 | |
| GO:0005576 | Extracellular region | CC | 126 | 5,08E-03 | 142 | 8,75E-06 | Late (1) | 62 | |
| GO:0005515 | Protein binding | MF | 273 | 6,38E-07 | Early (2) | 349 | 3,87E-12 | Lasting | 124 |
| GO:0003700 | Transcription factor activity, sequence-specific DNA binding | MF | 65 | 3,17E-05 | Early (1) | 82 | 3,50E-05 | Late (1) | 32 |
| GO:0043565 | Sequence-specific DNA binding | MF | 46 | 7,00E-05 | Early (1) | 68 | 1,00E-04 | Early (1) | 29 |
| GO:0044212 | Transcription regulatory region DNA binding | MF | 24 | 2,22E-04 | Early (1) | 30 | 8,00E-06 | Early (1) | 17 |
| GO:0008134 | Transcription factor binding | MF | 30 | 4,22E-04 | Early (1) | 34 | 4,93E-05 | Early (1) | 18 |
| GO:0001077 | Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MF | 33 | 5,06E-04 | Early (1) | 49 | 7,75E-06 | Early (3) | 19 |
| P5 | |||||||||
| GO:0016126 | Sterol biosynthetic process | BP | 15 | 1,36E-12 | Transient (1) | 1 | |||
| GO:0008202 | Steroid metabolic process | BP | 17 (1Up) | 7,85E-07 | Late (2) | 5 (4 up) | |||
| GO:0007623 | Circadian rhythm | BP | 15 | 1,28E-04 | Early (1) | 9 | |||
| GO:0016020 | Membrane | CC | 382 | 1,94E-12 | Transient (1) | 149 | |||
| GO:0005886 | Plasma membrane | CC | 247 | 1,96E-06 | Transient (1) | 99 | |||
| GO:0043025 | Neuronal cell body | CC | 47 | 6,77E-05 | Transient (1) | 17 | |||
| GO:0042734 | Presynaptic membrane | CC | 12 | 8,40E-04 | Transient (1) | 3 | |||
| GO:0003677 | DNA binding | MF | 104 | 3,99E-04 | Early (1) | 49 | |||
| P10 | |||||||||
| GO:0043066 | Negative regulation of apoptotic process | BP | 63 | 3,79E-05 | Early (1) | 27 | |||
| GO:0007399 | Nervous system development | BP | 34 | 3.32E-04 | Transient (2) | 13 | |||
| GO:0032760 | Positive regulation of tumor necrosis factor production | BP | 16 | 3,35E-04 | Late (1) | 8 | |||
| GO:0000790 | Nuclear chromatin | CC | 26 | 3,98E-06 | Early (1) | 14 | |||
| GO:0005829 | Cytosol | CC | 160 | 7,09E-06 | Late (3) | 58 | |||
| GO:0014069 | Postsynaptic density | CC | 26 | 5,85E-04 | Transient (1) | 5 | |||
BP indicates Gene ontology biological process classes, CC indicates Gene ontology cell component classes, MF indicates indicate Gene ontology molecular function classes. *N indicates the number of genes associated with GO-term. #n indicates the number of time points of significant determination of GO-term. Lasting determination indicates enrichment at the 4-time points, $apoptotic process at unique time points in the P10 brain never reached the 1E-3 threshold but reached significance when assessed over the entire period.