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. 2020 Dec 2;7:586652. doi: 10.3389/fmed.2020.586652

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Copyright © 2020 Wang, Wang, Cao, Jin, Zhang, Liu, Gao, Liang, Li and Shou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heparin decreases the expression levels of apoptosis-mediated proteins in vivo. (A,B) The protein expression of Bax/Bcl-2 and cleaved Caspase-3/Caspase-3 in HK-2 was analyzed by western blotting and quantified by densitometry. The mice were subjected to cecal ligation and puncture operation (CLP) surgery. At 2 h before the onset of CLP, the mice were treated with heparin. The levels of protein in the kidney were determined by western blotting and quantified by densitometry. (C) The mRNA expression of Bax/Bcl-2 was analyzed by SYBR Green qPCR. The ratio of Bax/Bcl-2 in the sepsis group was higher than that in the sham group. The ratio of Bax/Bcl-2 in the heparin intervention group was lower than that in the sepsis group. Data are presented as mean ± SD, n = 3 per group of the representative data from three independent experiments; *P < 0.05.