Table 3.
Univariate and multivariate Cox proportional hazard analysis for overall survival.
| Characteristic | No. of patients | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | ||
| Delta (†) | |||||
| High | 29 | 1.1(0.6-2.1) | 0.6 | – | – |
| Low Growth rate (α) |
26 55 |
- 3.6(0.7–16.1) |
- 0.11 |
- - |
- - |
| Surgery | |||||
| Yes | 10 | 0.3(0.13–0.9) | 0.02 | 0.5 (0.16–1.5) | 0.2 |
| No | 45 | – | – | – | – |
| Age (years) | 55 | 1(0.9–1.05) | 0.3 | – | – |
| Sex | |||||
| Female | 22 | 0.9 (0.49–1.7) | 0.8 | – | – |
| Male | 33 | – | – | – | |
| Stage | |||||
| I and II | 34 | 0.6(0.3–1.2) | 0.21 | – | – |
| III and IV | 21 | ||||
| Chemo/radiation therapy | |||||
| Yes | 43 | 1.6(0.82–3.9) | 0.15 | 1.2(0.5–3.2) | 0.6 |
| No | 12 | ||||
| Years between 1st and 2nd cancer | 55 | 0.94(0.8–0.99) | 0.01 | 0.95(0.9–0.99) | 0.04 |
| Delta (††) | * | * | |||
| High | 2 | 0.9 (0.02–6.2) | 0.9 | – | – |
| Low Growth rate (α) |
8 10 |
- 1.5(0.03–22.8) |
- 0.7 |
- - |
- - |
| Surgical margin | |||||
| Positive (R1) | 1 | 3.5 (1.5–15) | 0.03 | – | – |
| Negative (R0) | 9 | – | – | – | – |
| N Stage | |||||
| Positive (N1) | 4 | 11 (1.6–230) | 0.01 | – | – |
| Negative (N0) | 6 | – | – | – | – |
| Adjuvant chemo/radiation | |||||
| Yes | 9 | 0.2 (0.02–5.7) | 0.3 | – | – |
| No | 1 | ||||
(†)All patients who developed pancreatic cancer as a second primary (n = 55).
(††)Patients who underwent surgical resection (n = 10).
*No sufficient events to run multivariate analysis (data overfitting).