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. 2020 Dec 5;2020:3021750. doi: 10.1155/2020/3021750

Figure 3.

Figure 3

Combination therapy downregulates NLRP3 and inhibits microglia pyroptosis in SCI rats: (a) NLRP3/IBA-1 costaining detected by IF (scale bar = 50 μm); (b) protein expression levels of pro-caspase-1, pro-IL-1β, and pro-IL-18 determined using Western Blotting; (c) levels of IL-1β and IL-18 determined using ELISA; (d) neuron cell apoptosis detected using TUNEL (scale bar = 50 μm). “∗, #, &” indicated significant difference (p < 0.05), “∗” vs. Sham group, “#” vs. SCI group, and “&” vs. rats treated with monotherapy (USW/HUC-MSCs).