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Interactions of GAS5 and miRNAs in glioma pathogenesis. GAS5 inhibits the expression of miRNAs, including miR-222, miR-196-5P, miR-10b, miR-18a-5p, and miR-34a. GAS5-targeted miR-222, GAS5-targeted miR-196-5p, and GAS5-targeted miR-10b are involved in the pathogenesis of glioma through bmf/bcl2/Bax/PLXN C1/cofilin, FOXO1/PID1/MIIP and sirtuin 1/PI3K/AKT/MEK/ERK/PTEN, respectively.
