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Role of GAS5 in improving chemosensitivity in glioma. (A) PTEN loss promotes resistance to ERL chemotherapy, but activated EGFRvIII enhances ERL chemosensitivity. TFP enhances DOX chemosensitivity by FOXO1 chemosensitivity. (B) GAS5 inhibits drug-induced autophagy by activating the m-TOR signal pathway, leading to increased sensitivity to chemotherapy. During this period, the expression of autophagy substrate P62 increases and LC3II expression decreases.
