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Predicted role for GAS5 in the diagnosis and prognosis of glioma. (A) Polymorphism in the GAS5 gene can lead to a preliminary diagnosis of susceptibility to glioma by TFAP2A. (B) Expression of GAS5 contributes to an understanding of the prognosis of glioma. (C) GAS5 products SNORD76 and SNORD44, which may be targets for treatment of glioma, inhibit tumor growth by affecting cell cycle-related proteins and the caspase-dependent apoptosis pathway, respectively.
