Figure 2.

Local HT achieved precise melanoma homogenizations. (A) The H&E stained tumor sections showing sharp transition zone (black arrows) between histotripsy treated and untreated tumor region (n=3). Scale bar: 200μm (left image) and 100μm (right image). (B-D) HT therapy induced homogenizations of treated tumor regions (B) Pre-treatment image of a mouse tumor. (C) HT treatment produced hyperechoic regions during each pulse (indicated by the red circle). (D) Hypoechoic contrast at the end of the pulse was visible adjacent to the focal point (indicated by red arrow).